Form
Lyophilized powder
Purity
>=99% (HPLC)
Molecular Weight
2174.5 Da
Storage
2-8C, protected from light
Use
For research purposes only. Not for human or animal use.
CAS
1627580-64-6
Sequence
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Longevity
MOTS-C
$70.00
99%+ Purity
Lab Tested
Research Grade
Lyophilized
COA Available
Fast Shipping
About This Compound
MOTS-C
MOTS-C 10mg — Research Overview
MOTS-C is a mitochondria-derived peptide (MDP) encoded within the 12S rRNA region of the mitochondrial genome — one of the few peptides with a mitochondrial rather than nuclear genetic origin. It is studied for its roles in metabolic regulation, AMPK pathway activation, insulin sensitivity, and longevity-associated signaling.
Neogenesis Bio Labs supplies MOTS-C as a lyophilized peptide at ≥99% purity, verified by third-party HPLC and mass spectrometry analysis.
What Researchers Study MOTS-C For
- AMPK Activation — AMP-activated protein kinase pathway and cellular energy sensing research
- Insulin Sensitivity — glucose uptake, insulin receptor signaling, and metabolic flexibility studies
- Mitochondrial Biology — mitochondria-to-nucleus retrograde signaling and organelle communication pathway research
- Metabolic Regulation — folate cycle and methionine metabolism pathway interactions in preclinical models
- Longevity Research — age-associated metabolic decline, healthspan pathway studies, and mitochondrial aging models
- Exercise Biology — skeletal muscle energy utilization, fatigue resistance, and mitochondrial adaptation research
Frequently Asked Questions
What makes MOTS-C unique among research peptides?
MOTS-C is encoded in mitochondrial DNA rather than nuclear DNA — a rare distinction. Research suggests MOTS-C can translocate from mitochondria to the cytoplasm and nucleus, where it interacts with AMPK and other metabolic regulatory pathways as a mitochondrial stress response signal.
How does MOTS-C interact with the AMPK pathway?
MOTS-C has been shown in preclinical research to activate AMPK (AMP-activated protein kinase), a master energy sensor that promotes glucose uptake, fatty acid oxidation, and mitochondrial biogenesis. MOTS-C appears to influence AMPK through interactions with the folate cycle and one-carbon metabolism.
What reconstitution approach is standard?
Lyophilized MOTS-C is typically reconstituted with bacteriostatic water. Store at or below 4°C and use within 28 days. Store lyophilized powder at 2-8°C prior to reconstitution.
Is a Certificate of Analysis included?
Yes. Every vial ships with a third-party COA confirming compound identity, purity (≥99% HPLC), and peptide integrity.
For Research Use Only. MOTS-C supplied by Neogenesis Bio Labs is intended exclusively for in-vitro research, laboratory study, and scientific investigation. Not for human consumption, veterinary use, or clinical application.
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